硕士生导师、教授名单

胡蝶

发布时间：2021-09-03浏览次数：2813

职称：讲师  姓名：胡蝶

Email: butterflystudy@163.com


教育经历:

  • 2014.9~2017.6   江南大学        发酵工程专业            工学博士

  • 2011.9~2014.6   江南大学        生物化学与分子生学专业  硕博连读

  • 2007.9~2011.6   湖南工程学院    生物工程专业            工学学士


工作经历：

  • 2021.3~至今    錢櫃   錢櫃*食品学院          讲师

  • 2017.9~2020.9   江南大学   食品科学与工程博士后流动站    博士后


个人荣誉：

  • 2017年获江南大学“优秀毕业研究生”

  • 2016年获“博士研究生国家奖学金”

  •  2015年被评为“江南大学优博培育对象”

  • 2013年第九届“挑战杯”中国大学生创业计划竞赛校级“特等奖”(排名1)

  • 2012年第八届“挑战杯”中国大学生创业计划竞赛校级“二等奖”(排名1)

  • 2011年湖南省第九届“挑战杯”湖南省大学生课外学术科技作品竞赛省级“二等奖”(排名1)

  • 2010年湖南省大学生课外有机化学化工创新作品竞赛“三等奖”(排名1)

  • 2009年湖南省大学生课外有机化学化工创新作品竞赛“一等奖”(排名1)


社会兼职（社会兼职填是否担任过专业杂志编委、专业委员会委员、专业协会会员等）

中国化工学会会员


研究方向:

生物化工、酶工程、基因工程、酶分子改造、食品生物技术和手性生物催化


教学科研项目:

 1.江苏省自然科学基金资助项目，No. BK20180622，环氧化物水解酶AuEH2对映选择性的理性改造及其分子机制研究，2018/07-2021/06，20万，主持

 2.中国博士后科学基金一等资助，No. 2018M630522，环氧化物水解酶AuEH2突变体对映选择性提高的分子机理，2018/05-2019/12，8万，主持

 3.国家自然科学基金面上项目，No. 21676117，基于理性设计的新型菜豆环氧化物水解酶定向改造，2017/1-2020/12，67万元，参加

 4.国家自然科学基金面上项目，No. 31271811，基于理性化设计的β-甘露聚糖酶分子定向改造，2013/1-2016/12，77万元，已结题，参加


发表论文

  1. Hu D.; Hu B.C.; Hou X.D.; Zhang D.; Lei Y.Q.; Rao Y.J.; Wu M. C. Structure-guided regulation in the enantioselectivity of an epoxide Hydrolase to produce enantiomeric monosubstituted epoxides and vicinal diols via kinetic resolution, Organic Letters, 2022, 24(9): 1757-1761

  2. Wen Z.;Hu D.; Hu B. C.; Zhang D.; Huang J.F.; Min-Chen Wu. Structure-guided improvement in the enantioselectivity of an Aspergillus usamii epoxide hydrolase for the gram-scale kinetic resolution of ortho-trifluoromethyl styrene oxide. Enzyme and Microbial Technology 2021,146.109778.

  3. Hu D.; Hu B.C.; Wen Z.; Zhang D.; Liu Y.Y.; Zang J.; Wu M.C.; Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity. Int. J. Biol. Macromol. 2021, 169, 1-7.

  4. Hu, D.; Zong, X. C.; Xue, F.; Li, C.; Hu, B. C.; Wu, M. C. Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides. Chem. Commun. 2020, 56, 2799-2802.

  5. Hu, D.; Wen, Z.; Li, C.; Hu, B. C.; Zhang, T.; Li, J. F.; Wu, M. C. Characterization of a robust glucose 1-dehydrogenase, SyGDH, and its application in NADPH regeneration for the asymmetric reduction of haloketone by a carbonyl reductase in organic solvent/buffer system. Process. Biochem. 2020, 89, 55-62.

  6. Hu, B.C.; Hu, D. (共一); Zhang, D.; Wen, Z.; Zang, J.; Wu, M.C. Manipulating the regioselectivity of a Solanum lycopersicum epoxide hydrolase for the enantioconvergent biosynthesis of enantiopure alkane- and alkene-1,2-diols. Catal. Sci. Technol. 2020, 10, 5886-5895

  7. Hu, B. C.; Hu, D.(共一); Li, C.; Xu, X. F.; Wen, Z.; Wu, M. C. Near-perfect kinetic resolution of racemic p-chlorostyrene oxide by SIEH1, a novel epoxide hydrolase from Solanum lycopersicum with extremely high enantioselectivity. Int. J. Biol. Macromol.2020, 147, 1213-1220.

  8. Xu, X. F.; Hu, D.(共一); Hu, B. C.; Li, C.; Liu, Y. Y.; Wu, M. C. Near-perfect kinetic resolution of o-methylphenyl glycidyl ether by RpEH, a novel epoxide hydrolase from Rhodotorula paludigena JNU001 with high stereoselectivity.Appl. Microbiol. Biotechnol. 2020, 104, 6199-6210.  

  9. Hu, D.; Tang, C. D.; Li, C.; Kan, T. T.; Shi, X. L.; Feng, L.; Wu, M. C. Stereoselective hydrolysis of epoxides by reVrEH3, a novel Vigna radiata epoxide hydrolase with high enantioselectivity or high and complementary regioselectivity. J. Agric. Food. Chem.2017, 65, 9862-9871.

  10.  Wang, R.; Hu, D.(共一); Zong, X. C.; Li, J. P.; Ding, L.; Wu, M. C.; Li, J. Enantioconvergent hydrolysis of racemic styrene oxide at high concentration by a pair of novel epoxide hydrolases into (R)-phenyl-1,2-ethanediol. Biotechnol. Lett.2017, 39, 1917-1923.  

  11.  Li, C.; Hu, D. (共一); Zong, X. C.; Deng, C.; Feng, L.; Wu, M. C.; Li, J. F. Asymmetric hydrolysis of styrene oxide by PvEH2, a novel Phaseolus vulgaris epoxide hydrolase with extremely high enantioselectivity and regioselectivity. Catal. Commun. 2017, 102, 57-61.  

  12. Hu, D.; Wang, R.; Shi, X. L.; Ye, H. H.; Wu, Q.; Wu, M. C.; Chu, J. J. Kinetic resolution of racemic styrene oxide at a high concentration by recombinant Aspergillus usamii epoxide hydrolase in an n-hexanol/buffer biphasic system. J. Biotechnol.2016, 236, 152-158.  

  13. Hu, D.; Li, J. F.; Wu, Q.; Zang, J.; Cheng, J. Q.; Wu, M. C. Improved temperature characteristics of an Aspergillus oryzae GHF11 xylanase, by in silico design and site-directed mutagenesis. Biotechnol. Bioproc. E.2016, 21, 704-711.

  14. Ye, H. H.; Hu, D. (共一); Shi, X. L.; Wu, M. C.; Deng, C.; Li, J. F. Directed modification of a novel epoxide hydrolase from Phaseolus vulgaris to improve its enantioconvergence towards styrene epoxides. Catal. Commun.2016, 87, 32-35.  

  15. Hu, D.; Ye, H. H.; Wu, M. C.; Feng, F.; Zhu, L. J.; Yin, X.; Li, J. F. Chemoenzymatic preparation of (S)-p-nitrostyrene oxide from p-nitrophenacyl bromide by recombinant Escherichia coli cells expressing a novel halohydrin dehalogenase. Catal. Commun.2015, 69, 72-75.  

  16. Hu, D.; Tang, C. D.; Yang, B. A.; Liu, J. C.; Yu, T.; Deng, C.; Wu, M. C. Expression of a novel epoxide hydrolase of Aspergillus usamii E001 in Escherichia coli and its performance in resolution of racemic styrene oxide. J. Ind. Microbiol. Biotechnol.2015, 42, 671-680.   

  17. Yin, X.; Hu, D. (共一作); Li, J. F.; He, Y.; Zhu, T. D.; Wu, M. C. Contribution of disulfide bridges to the thermostability of a type A feruloyl esterase from Aspergillus usamii. PLoS One2015, 10. 1-16.  

  18. 苏永君,胡蝶,胡博淳,李闯,文正,章晨,邬敏辰.定点突变提高环氧化物水解酶AuEH2催化对甲基苯基缩水甘油醚的对映选择性.中国生物工程杂志, 2020, 40(3): 88-95.

  19. 阚婷婷,宗迅成,苏永君,王婷婷,李闯,胡蝶*,邬敏辰*.定点突变改善PvEH1对邻甲基苯基缩水甘油醚的催化特性.中国生物工程杂志, 2019, 39(6): 9–16.

  20. 董运海,胡蝶,邬敏辰*,唐诗涵,王春娟,李剑芳.定点突变改善β-甘露聚糖酶AuMan5A的酶学性质.食品与生物技术学报, 2017, 36(8): 819-825.

  21. 朱利娟,胡蝶,储亚琴,臧嘉,余涛,邬敏辰*.多酶偶联催化制备手性化合物 (S)-环氧苯乙烷.食品与生物技术学报, 2017, 36(5): 473-478.

  22. 吴芹，胡蝶，李雪晴，袁风娇，李剑芳.邬敏辰. Y13F定点突变改良米曲霉中温木聚糖酶的温度特性.中国生物工程杂志. 2016, 36(12): 36-41.

  23. 刘高磊,胡蝶,邬敏辰*,殷欣,汪俊卿.内切葡聚糖酶与木聚糖酶在毕赤酵母中的共分泌表达.食品与生物技术学报, 2015, (3): 253-259.

  24. 冯峰,胡蝶,余涛,曾妍,邬敏辰*.新型卤代醇脱卤酶基因的克隆、序列分析及表达.食品与生物技术学报, 2015, (5): 494-500.

  25. 胡蝶,朱利娟,邬敏辰,汪俊卿,唐存多,冯峰,余涛.宇佐美曲霉环氧化物水解酶基因的克隆与生物信息学分析.食品与生物技术学报. 2013. 32(12): 1244-1252.


授权专利

 1.邬敏辰;胡蝶;王瑞;叶慧华;唐诗涵;李剑芳;一种酶法制备(S)-环氧苯乙烷的方法,授权日: 2019-12-24,中国, ZL201610535106.0.

 2.邬敏辰;胡蝶;王瑞;叶慧华;李剑芳;一种对映选择性提高的宇佐美曲霉环氧化物水解酶突变体,授权日: 2019-11-08,中国, ZL201610534898.X.  

 3.邬敏辰;叶慧华;胡蝶;石小玲;吴芹;李剑芳;一种催化活性和对映归一性提高的菜豆环氧化物水解酶突变体,授权日: 2019-07-23,中国, ZL201610534520.X.

 4.邬敏辰;王瑞;胡蝶;李闯;宗讯成;李剑芳;一种双酶催化外消旋环氧苯乙烷制备(R)-苯乙二醇的方法,授权日: 2019-05-17,中国, ZL201610926649.5.

 5.邬敏辰;胡蝶;叶慧华;李剑芳;朱利娟;余涛;一种环氧化物水解酶突变体的设计和制备方法,授权日: 2017-7-14,中国, ZL201410752769.9




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